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Comparative Study
. 2013 Oct 15;9(10):1049-55.
doi: 10.5664/jcsm.3080.

Short duration of sleep is associated with hyperleptinemia in Taiwanese adults

Malcolm Koo  1 , Ning-Sheng Lai, Jui-Kun Chiang
Affiliations
Comparative Study

Short duration of sleep is associated with hyperleptinemia in Taiwanese adults

Malcolm Koo et al. J Clin Sleep Med. .

Abstract

Background: Higher plasma levels of leptin have been associated with increased cardiometabolic risk. The aim of this study was to investigate the association between short duration of sleep and hyperleptinemia in Taiwanese adults.

Methods: We examined the association between duration of sleep and hyperleptinemia in 254 men and women recruited from the physical examination center at a regional hospital in southern Taiwan. Hyperleptinemia was defined as a plasma leptin level of 8.13 ng/mL and above. Short sleep duration was defined as < 6.5 h/day. Multiple logistic regression analysis was used to assess the association between short duration of sleep and hyperleptinemia.

Results: In females, short duration of sleep (< 6.5 h/day; OR = 2.15, 95% CI = 0.99-4.78), greater hip circumference (OR = 3.00, CI = 1.13-8.78), higher percent body fat (OR = 1.75, CI = 1.07-2.95), and higher white blood cell counts (OR = 1.67, CI = 1.26-2.28) were associated with an increased risk of hyperleptinemia. In males, greater body weight was significantly associated with an increased risk of hyperleptinemia (OR = 3.55, 95% CI = 1.46-10.23). There was also a trend of association (p = 0.096) between short duration of sleep and an increased risk of hyperleptinemia (OR = 4.98, 95% CI = 0.80-42.40).

Conclusions: In this study of healthy Taiwanese adults, short duration of sleep was significantly associated with hyperleptinemia in women, and the association was independent of adiposity.

Keywords: Sleep duration; adiposity; gender; leptin; leptin resistance.

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Figures

Figure 1
Figure 1. Plot of covariate-adjusted nonparametric smoothing from generalized additive model of sleep duration and probability of hyperleptinemia
Figure 2
Figure 2. Receiver-operating characteristic curves for short duration of sleep (< 6.5 h/day) in predicting hyperleptinemia in males and females
None
See this image and copyright information in PMC

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