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Meta-Analysis
. 2013 Nov;132(5):871-81.
doi: 10.1542/peds.2013-1713. Epub 2013 Oct 14.

Reliability of transcutaneous bilirubin devices in preterm infants: a systematic review

Gaurav Nagar  1 , Ben Vandermeer, Sandra Campbell, Manoj Kumar
Affiliations
Meta-Analysis

Reliability of transcutaneous bilirubin devices in preterm infants: a systematic review

Gaurav Nagar et al. Pediatrics. 2013 Nov.

Abstract

Background and objective: Transcutaneous bilirubin (TcB) devices are widely used for the estimation of serum bilirubin levels in term and near-term infants. Our objective was to review the diagnostic accuracy of TcB devices in preterm infants.

Methods: Medline, Embase, Cochrane library, Cumulative Index to Nursing and Allied Health Literature, and Scopus were searched (from database inception date until December 2012). Additional citations were identified by using the bibliographies of selected articles and from conference proceedings. The studies were included if they compared TcB with total serum bilirubin in preterm infants before phototherapy and presented data as correlation coefficients or as Bland-Altman difference plots. Data were extracted by 1 reviewer and checked for accuracy by the second reviewer. An assessment tool (quality assessment of diagnostic accuracy studies) was used for risk of bias assessments.

Results: Twenty-two studies met the inclusion criteria; 21 studies reported results as correlation coefficients, with pooled estimates of r = 0.83 for each site of measurement. Pooled estimates in infants <32 weeks' gestation were similar to the overall preterm population (r = 0.89 [95% confidence interval: 0.82-0.93]). For the 2 commonly used TcB devices (ie, JM103 and BiliCheck), the results were comparable at the forehead site, although the JM103 device exhibited better correlation at the sternum. Analysis of the Bland-Altman plots (13 studies) revealed negligible bias in measurement at the forehead or sternum site by using either the JM-103 or BiliCheck device; however, the JM-103 device exhibited better precision than the BiliCheck (SD for TcB - total serum bilirubin differences: 24.3 and 31.98 µmol/L, respectively).

Conclusions: The TcB devices reliably estimated bilirubin levels in preterm infants and could be used in clinical practice to reduce blood sampling.

Keywords: Bland-Altman difference plots; correlation coefficient; meta-analysis; systematic review; transcutaneous bilirubin.

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