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Comment
. 2013 Nov;133(11):2503-2504.
doi: 10.1038/jid.2013.361.

IL36RN mutations in generalized pustular psoriasis: just the tip of the iceberg?

Francesca Capon  1
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Free article
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IL36RN mutations in generalized pustular psoriasis: just the tip of the iceberg?

Francesca Capon. J Invest Dermatol. 2013 Nov.
Free article

Abstract

As IL36RN mutations are a cause of generalized pustular psoriasis (GPP), three recent investigations attempted to correlate the IL36RN genotype with GPP clinical presentations. These studies found that IL36RN mutations account for only a fraction of GPP cases presenting with concomitant psoriasis vulgaris (PV; common or typical psoriasis). Pathogenic alleles were also found in control populations, indicating that environmental triggers and/or modifier genes may contribute to the disease.

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