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Review
. 2013;9(10):e1003603.
doi: 10.1371/journal.ppat.1003603. Epub 2013 Oct 10.

Antivirulence therapy for animal production: filling an arsenal with novel weapons for sustainable disease control

Tom Defoirdt  1
Affiliations
Review

Antivirulence therapy for animal production: filling an arsenal with novel weapons for sustainable disease control

Tom Defoirdt. PLoS Pathog. 2013.
No abstract available

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Conflict of interest statement

The author has declared that no competing interests exist.

Figures

Figure 1
Figure 1. Simplified schematic representation of virulence regulatory systems based on detection of signal molecules in animal pathogenic bacteria.
These include (left) quorum sensing based on acylhomoserine lactones (AHL) and (right) quorum sensing in vibrios and catecholamine stress hormone sensing. For each type of system, examples of natural ligands, receptor inhibitors, and other inhibiting agents are shown. Dioxazaborocane is an inhibitor of AI-2 sensing in V. harveyi and LED209 is an inhibitor of catecholamine sensing in E. coli. The signal transduction inhibitors are inhibitors of quorum sensing signal transduction in vibrios.
See this image and copyright information in PMC

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