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. 2013 Oct 17;369(16):1565-7.
doi: 10.1056/NEJMc1306509.

TREM2 and neurodegenerative disease

Priya Rajagopalan, Derrek P Hibar, Paul M Thompson

TREM2 and neurodegenerative disease

Priya Rajagopalan et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1
At a 24-month follow-up scan, these 3D regression coefficient maps show brain volume differences in the temporal lobe associated with carrying the TREM2 risk allele. The risk allele carriers showed significantly accelerated brain atrophy from 1.4–3.3% in the statistical region of interest (FDR critical p = 0.0036; q = 0.05). Statistical tests were performed using permutation tests, which are robust in the presence of outliers and small sample sizes (see Supplement). The figure is shown in the radiological convention (left side of the image is the right hemisphere).
See this image and copyright information in PMC

Comment in

  • TREM2 and neurodegenerative disease.
    Jonsson T, Stefansson K. Jonsson T, et al. N Engl J Med. 2013 Oct 17;369(16):1568-9. doi: 10.1056/NEJMc1306509. N Engl J Med. 2013. PMID: 24131183 No abstract available.

References

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