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Case Reports
. 2014 Jan;46(1):69-72.
doi: 10.3109/00365548.2013.837957. Epub 2013 Oct 16.

Cerebrospinal fluid penetration of tigecycline

Carlo Pallotto  1 , Maurizio Fiorio, Antonio D'Avolio, Alessio Sgrelli, Franco Baldelli, Giovanni Di Perri, Giuseppe Vittorio De Socio
Affiliations
Case Reports

Cerebrospinal fluid penetration of tigecycline

Carlo Pallotto et al. Scand J Infect Dis. 2014 Jan.

Abstract

We report, in a clinical setting, the tigecycline concentration and area under the concentration-time curve (AUC) - both in blood and in cerebrospinal fluid (CSF) - of a patient with a ventriculo-atrial shunt infection. Tigecycline weakly penetrates CSF the CSF-to-serum concentration ratio was 0.079 and CSF-to-serum AUC(0-12) ratio was 0.067.

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