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Review
. 2013 Oct 17;5(5):48.
doi: 10.1186/alzrt213. eCollection 2013.

Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

Krista L Moulder  1 , B Joy Snider  1 , Susan L Mills  1 , Virginia D Buckles  1 , Anna M Santacruz  1 , Randall J Bateman  1 , John C Morris  1
Affiliations
Review

Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

Krista L Moulder et al. Alzheimers Res Ther. .

Abstract

The Dominantly Inherited Alzheimer Network (DIAN) is an international registry of individuals at risk for developing autosomal dominant Alzheimer's disease (AD). Its primary aims are to investigate the temporal ordering of AD pathophysiological changes that occur in asymptomatic mutation carriers and to identify those markers that herald the transition from cognitive normality to symptomatic AD. DIAN participants undergo longitudinal evaluations, including clinical and cognitive assessments and measurements of molecular and imaging AD biomarkers. This review details the unique attributes of DIAN as a model AD biomarker study and how it provides the infrastructure for innovative research projects, including clinical trials. The recent design and launch of the first anti-amyloid-beta secondary prevention trial in AD, led by the related DIAN Trials Unit, also are discussed.

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Figures

Figure 1
Figure 1
Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) participant randomization flow. MC, mutation carrier; NC, non-carrier.
See this image and copyright information in PMC

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