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Editorial
. 2013 Dec 1;12(23):3581-2.
doi: 10.4161/cc.26824. Epub 2013 Oct 21.

Gfi1: a unique controller of T(reg) cells

Lewis Zhichang Shi  1 , Hongbo Chi
Affiliations
Editorial

Gfi1: a unique controller of T(reg) cells

Lewis Zhichang Shi et al. Cell Cycle. .
No abstract available

Keywords: CD103; CD73; Foxp3; Gfi1; IL-2; Treg development; tumor immunity.

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Figures

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Figure 1. Control of Foxp3+ nTreg cells and antitumor immunity by Gfi1. Loss of Gfi1 in conventional T cells (Tconv) leads to increased secretion of IL-2, which promotes nTreg cell expansion in the thymus and periphery. Gfi1 deletion also upregulates Treg effector molecules CD103 and CD73. Collectively, Gfi1 deficiency in T cells dampens antitumor immunity. ↑, increased expression or cellularity.
See this image and copyright information in PMC

Comment on

  • Shi LZ, et al. Proc Natl Acad Sci U S A. 2013;110:E3198–205. doi: 10.1073/pnas.1300950110. doi: 10.1073/pnas.1300950110

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