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Case Reports
. 2013 Sep;19(3):315-9.
doi: 10.3350/cmh.2013.19.3.315.

Epithelioid hemangioendothelioma of the liver

Keum Ha Choi  1 , Woo Sung Moon
Affiliations
Case Reports

Epithelioid hemangioendothelioma of the liver

Keum Ha Choi et al. Clin Mol Hepatol. 2013 Sep.
No abstract available

Keywords: Hemangioendothelioma, Epithelioid; Liver.

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Conflict of interest statement

The authors have no conflicts to disclose.

Figures

Figure 1
Figure 1
Magnetic resonance imaging findings. (A) Axial T2-weighted image shows high signal intensity in the central zone (arrow) and concentric alteration in signal intensity, corresponding to regions of different histology. (B) Axial T1-weighted image shows low signal intensity in the central sclerotic zone (arrow).
Figure 2
Figure 2
Macroscopic and histological examination. (A) The cut surface reveals a firm, yellowish-white mass with irregular margins and central fibrosis (No.1: central zone, No.2: peripheral zone, No.3: normal liver). (B) Histological findings correspond to the gross appearance of the tumor (No.1: central zone, No.2: peripheral zone, No.3: normal liver) (H&E, ×40). (C) At the peripheral zone, epithelioid tumor cells form polypoid projections (arrows) in dilated sinusoids, and epithelioid cells show atypical nuclei with prominent nucleoli (inlet, arrowheads) (H&E, ×200). (D) At the central zone, the dendritic tumor cells are embedded in myxochondroid and sclerotic stroma. Characteristically, the tumor cells have intracytoplasmic vacuoles containing red blood cells, which resemble signet ring-like structures (inlet, arrowhead) (H&E, ×200).
Figure 3
Figure 3
Immunohistochemical results. (A) The tumor cells synthesize factor VIII-related antigen (von Willebrand factor) in the cytoplasm and neoplastic vascular lumens. (B) The tumor cells with CD34 positivity (right arrow), in contrast to the neighboring normal hepatocytes, which show no immunoreactivity for CD34 (left arrowhead) and the immunoreactivity pattern for CD31 is identical to CD34 (figure not shown).
See this image and copyright information in PMC

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References

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