Review
[Sphingosine kinase 1 and tumor]
[Article in
Chinese]
Affiliations
- PMID: 24133963
Item in Clipboard
Review
[Sphingosine kinase 1 and tumor]
[Article in
Chinese]
Yao Xue Xue Bao.
2013 Jul.
Abstract
Sphingolipids as an important regulator play a critical role in the cell biological functions. Among them, ceramide (Cer) and sphingosine (Sph) induce apoptosis and inhibit cell proliferation; on the contrary sphingosine 1-phosphate (S1P) promotes cell survival and proliferation. The balance between ceramide/sphingosine and S1P forms a so-called "sphingolipid-rheostat", which decides the cell fate. Sphingosine kinases, which catalyze the phosphorylation of sphingosine to S1P, are critical regulators of this balance. Here, we review the role of sphingosine kinase 1 (SphK1) in regulating fundamental biological processes and tumorigenesis and the potential of SphK1 as a new target for cancer therapeutics.
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