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. 1985 Oct;82(20):7020-4.
doi: 10.1073/pnas.82.20.7020.

Interleukin 2-dependent release of interleukin 3 activity by T4+ human T-cell clones

A A Ythier, M Abbud-Filho, J M Williams, R Loertscher, M W Schuster, A Nowill, J A Hansen, D Maltezos, T B Strom

Interleukin 2-dependent release of interleukin 3 activity by T4+ human T-cell clones

A A Ythier et al. Proc Natl Acad Sci U S A. 1985 Oct.

Abstract

We have isolated and studied two alloreactive, T4+, human lymphocyte clones that release interleukin 2 (IL-2) and interleukin 3 (IL-3) bioactivities upon stimulation with IL-2, alloantigen, or Sepharose-conjugated antibodies directed against the T3 protein. Anti-IL-2 receptor monoclonal antibodies block IL-2-, alloantigen-, or anti-T3-stimulated IL-3 release. Hence, release of IL-3 activity in each circumstance is rigorously dependent upon activation of the IL-2 receptor. Even low, nonmitogenic concentrations of recombinant IL-2 stimulated IL-3 release.

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References

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