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Review
. 2013 Dec;29(6):773-8.
doi: 10.1007/s12264-013-1382-3. Epub 2013 Oct 17.

Role of the PTEN signaling pathway in autism spectrum disorder

Jing-Wen Lv  1 , Tian-Lin Cheng, Zi-Long Qiu, Wen-Hao Zhou
Affiliations
Review

Role of the PTEN signaling pathway in autism spectrum disorder

Jing-Wen Lv et al. Neurosci Bull. 2013 Dec.

Abstract

Autism is an etiologically heterogeneous group of neurodevelopmental disorders, diagnosed mostly by the clinical behavioral phenotypes. The concept that the tumor-related gene PTEN plays a critical role in autism spectrum disorder has emerged over the last decade. In this review, we focus on the essential role of the PTEN signaling pathway in neuronal differentiation and the formation of neural circuitry, as well as genetic mouse models with Pten manipulations. Particularly, accumulated data suggest that the effect of PTEN on neural stem-cell development contributes significantly to the pathophysiology of autism spectrum disorders.

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References

    1. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997;275(5308):1943–1947. doi: 10.1126/science.275.5308.1943. - DOI - PubMed
    1. Endersby R, Baker SJ. PTEN signal ing in brain: neuropathology and tumorigenesis. Oncogene. 2008;27(41):5416–5430. doi: 10.1038/onc.2008.239. - DOI - PubMed
    1. Blumenthal GM, Dennis PA. PTEN hamartoma tumor syndromes. Eur J Hum Genet. 2008;16(11):1289–1300. doi: 10.1038/ejhg.2008.162. - DOI - PMC - PubMed
    1. Waite KA, Eng C. BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Hum Mol Genet. 2003;12(6):679–684. doi: 10.1093/hmg/ddg069. - DOI - PubMed
    1. Inoki K, Li Y, Zhu T, Wu J, Guan K L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002;4(9):648–657. doi: 10.1038/ncb839. - DOI - PubMed

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