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. 2013 Aug;6(2):485-488.
doi: 10.3892/etm.2013.1149. Epub 2013 Jun 7.

A correlation analysis between the expression of pregnancy-associated plasma protein A in basal decidual cells and recurrent spontaneous abortion

Ying Zhang  1 , Qian Zhao, Ya Xie, Ke Su, Jun Yang, Li Yang
Affiliations

A correlation analysis between the expression of pregnancy-associated plasma protein A in basal decidual cells and recurrent spontaneous abortion

Ying Zhang et al. Exp Ther Med. 2013 Aug.

Abstract

The aim of this study was to investigate the correlation between the expression of pregnancy-associated plasma protein A (PAPP-A) in basal decidual cells and recurrent spontaneous abortion (RSA). A total of 39 patients with a history of RSA were enrolled into the RSA group. A further 30 females who had experienced normal pregnancy were enrolled into the control group. The mRNA expression of PAPP-A in basal decidual cells was analyzed using real-time PCR. The distribution and expression of PAPP-A protein levels in basal decidual cells were analyzed by immunohistochemistry. The correlation between PAPP-A protein levels and RSA was analyzed. The levels of PAPP-A mRNA in the RSA group were significantly decreased, compared with the control group (P<0.05). Consistent with the mRNA levels, the protein levels of PAPP-A were also significantly lower in the RSA group compared with the control group (P<0.05). Multivariate logistic analysis indicated that the suppression of PAPP-A was one of the risk factors for RSA. Furthermore, Hosmer-Lemeshow analysis suggested that the expression levels of PAPP-A is an important factor for predicting RSA. In conclusion, the expression levels of the PAPP-A protein were significantly reduced in basal decidual cells of the RSA group compared with the control group. Therefore, PAPP-A is likely to play an important role in RSA.

Keywords: basal decidual cells; correlation; pregnancy-associated plasma protein A; prognosis; recurrent spontaneous abortion.

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Figures

Figure 1.
Figure 1.
PAPP-A mRNA level of decidual in the RSA and control groups. *P<0.05.
Figure 2.
Figure 2.
Tissue distribution and quantitative results of the PAPP-A protein between the RSA and control group. *P<0.05.
See this image and copyright information in PMC

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