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. 2013 Sep;6(3):713-718.
doi: 10.3892/ol.2013.1466. Epub 2013 Jul 15.

Clinical application of iodine-eluting stent in patients with advanced esophageal cancer

Zhenbo Dai  1 , Dejun Zhou, Jianzhang Hu, Lei Zhang, Yunshou Lin, Jing Zhang, Fengling Li, Peng Liu, Hua Li, Fuliang Cao
Affiliations

Clinical application of iodine-eluting stent in patients with advanced esophageal cancer

Zhenbo Dai et al. Oncol Lett. 2013 Sep.

Abstract

The aim of the present study was to compare the clinical effectiveness of an iodine-eluting stent with a conventional stent in patients with advanced esophageal cancer. Patients with malignant esophageal cancer were randomly assigned to receive a conventional stent (group A) or an iodine-eluting stent (group B). Following implantation, the relief from dysphagia, survival time, routine blood tests, thyroid function examination and complications were compared in the two groups. Groups A and B consisted of 36 and 31 patients, respectively. The mean value that the dysphagia score decreased by was significantly lower in group A (0.83) compared with group B (1.65). The median survival time was longer in group B compared with group A (P=0.0022). No significant differences were observed in the severe complications between the two groups (P=0.084). The iodine-eluting esophageal stent is a relatively safe, feasible and effective treatment for malignant esophageal strictures.

Keywords: esophageal cancer; stent.

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Figures

Figure 1
Figure 1
(A) Radioactive stent and (B) its auxiliary equipment.
Figure 2
Figure 2
Mean dysphagia score during follow-up. The dysphagia grades significantly improved in the two groups and the mean decreased value of dysphagia score was 0.83 in group A and 1.65 in group B. There was a significant difference between the two groups (P=0.002; Student’s t-test). d, days; m, months.
Figure 3
Figure 3
Kaplan-Meier curves. Comparison of overall survival between group A (a conventional covered stent) and group B (an iodine-eluting esophageal stent). The median overall survival period was longer in group B compared with that in group A; 145 (95% CI, 85–195) days vs. 90 (95% CI, 74–107) days, respectively.
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