Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Jul;29(4):334-7.

Early protection to Junín virus of guinea pig with an attenuated Junín virus strain

L B de Guerrero, M C Boxaca, E Malumbres, C Dejean, E Caruso
  • PMID: 2413752

Early protection to Junín virus of guinea pig with an attenuated Junín virus strain

L B de Guerrero et al. Acta Virol. 1985 Jul.

Abstract

Inoculation of guinea pigs with attenuated XJO Junín virus (JV) strain confers protection against challenge with pathogenic XJ-JV strain starting as early as 3 days post infection (p.i.). The protection increased continuously up to 100% by 30 days p.i. Neither stimulation of non-specific cell mediated mechanisms by previous BCG sensitization nor circulating interferon (IFN) seemed essential for such protection. The early detection of the virus in guinea pig organs considered the site of primary JV multiplication suggests that early resistance phenomenon was attributed mainly to direct viral interference.

PubMed Disclaimer

MeSH terms