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Comment
. 2013 Oct 17;39(4):631-2.
doi: 10.1016/j.immuni.2013.10.002.

A "big data" view of the tumor "immunome"

Nicholas P Restifo  1
Affiliations
Comment

A "big data" view of the tumor "immunome"

Nicholas P Restifo. Immunity. .

Abstract

Tumors are complex masses containing not just neoplastic cells but also stromal cells, neovasculature, and a gamut of immune cells. In this issue, Bindea et al. (2013) identify a surprising new "immune landscape" associated with prolonged disease-free survival.

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Figures

Figure
Figure
Immune cells in tumor. Tumors masses are complex mixtures of cells that contain stromal cells, vasculature and a wide array of immune cells. Unsupervised correlation matrix of intra-tumor ‘immunome’ reveals that of the 28 cell types that were specifically analyzed, the strongest correlations with increased disease-free survival were with CTL, Tfh and B cells (shown in bold), which furthermore were correlated with each other.
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