Anti-tau antibodies: hitting the target
- PMID: 24139027
- DOI: 10.1016/j.neuron.2013.10.009
Anti-tau antibodies: hitting the target
Abstract
Immunotherapies targeting tau in mouse models of human tauopathies could have disease-modifying effects. In this issue of Neuron, Yanamandra et al. (2013) use tau antibodies, which effectively block tau seeding in culture, to attenuate tauopathy and improve cognition in mutant tau mouse models.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.Neuron. 2013 Oct 16;80(2):402-414. doi: 10.1016/j.neuron.2013.07.046. Epub 2013 Sep 26. Neuron. 2013. PMID: 24075978 Free PMC article.
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