Dynamins are forever: MxB inhibits HIV-1
- PMID: 24139395
- DOI: 10.1016/j.chom.2013.10.002
Dynamins are forever: MxB inhibits HIV-1
Abstract
Human MxA (MX1) protein is an interferon-induced restriction factor for a diverse range of viruses, whereas the related MxB (MX2) protein was thought to lack such activity. Three recent papers, including one in this issue of Cell Host & Microbe, show that MxB inhibits human immunodeficiency virus type 1 (HIV-1) infection.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.Nature. 2013 Oct 24;502(7472):559-62. doi: 10.1038/nature12542. Epub 2013 Sep 18. Nature. 2013. PMID: 24048477 Free PMC article.
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The interferon-inducible MxB protein inhibits HIV-1 infection.Cell Host Microbe. 2013 Oct 16;14(4):398-410. doi: 10.1016/j.chom.2013.08.015. Epub 2013 Sep 19. Cell Host Microbe. 2013. PMID: 24055605
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MX2 is an interferon-induced inhibitor of HIV-1 infection.Nature. 2013 Oct 24;502(7472):563-6. doi: 10.1038/nature12653. Epub 2013 Oct 13. Nature. 2013. PMID: 24121441 Free PMC article.
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