Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jan;304(1):79-92.
doi: 10.1016/j.ijmm.2013.09.002. Epub 2013 Sep 4.

The promise of riboswitches as potential antibacterial drug targets

Christina E Lünse  1 , Anna Schüller  1 , Günter Mayer  2
Affiliations
Review

The promise of riboswitches as potential antibacterial drug targets

Christina E Lünse et al. Int J Med Microbiol. 2014 Jan.

Abstract

Riboswitches represent promising novel RNA structures for developing compounds that artificially regulate gene expression and, thus, bacterial growth. The past years have seen increasing efforts to identify metabolite-analogues which act on riboswitches and which reveal antibacterial activity. Here, we summarize the current inventory of riboswitch-targeting compounds, their characteristics and antibacterial potential.

Keywords: Adenine; FMN; Glucosamin-6-phosphate; Guanine; Lysine; Metabolite; Riboswitch; Ribozyme; TPP.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources