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. 1985 Nov;72(5 Pt 2):IV39-46.

Overview of the processes of delivery: flow, transmembrane transport, reaction, and retention

J B Bassingthwaighte

Overview of the processes of delivery: flow, transmembrane transport, reaction, and retention

J B Bassingthwaighte. Circulation. 1985 Nov.
No abstract available

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Figures

FIGURE 1
FIGURE 1
Capillaries in dog myocardium. The heart was perfused with a white silicone elastomer (Microfil, Canton Biomedical Products, Boulder) and cleared by dehydration with ethanol and ethanol replacement with methylsalicylate. Capillaries average 5 µm in diameter, and number in cross section 3000 to 3300/mm2, or about 1/myocyte. From an experiment by Bassingthwaighte et al.
FIGURE 2
FIGURE 2
Distribution of flows in myocardium of left ventricle. Composite of microsphere distributions in 13 awake baboons. Each heart provided four to six flow distributions for a total of 53 distributions (some at rest, others during exercise and heating), which summarize 8800 estimates of regional flow. Data from King et al.
FIGURE 3
FIGURE 3
Possible mechanisms of transport of fatty acids across the capillary wall and cell membrane. Routes are (1) diffusion between endothelial cells, (2) lateral diffusion in membrane, (3) and (5) passive diffusion across cell membrane and inside cell, and (4) and (6) carrier-mediated transport across membranes.
FIGURE 4
FIGURE 4
Steric hindrance in passage through aqueous channels between endothelial cells. As the reflection coefficient approaches unity, the permeability to the molecule goes to zero. Thin line represents calculations of Bean; thick line represents improved computation by Lightfoot et al., with points from Lewellen and interpolated dashed line.
FIGURE 5
FIGURE 5
A model for capillary-tissue exchange in the heart. F = flow; PS = permeability surface area; G = consumption or reaction; V = volume. pl = plasma; ec = endothelial cell (l. luminal or a, abluminal); isf = interstitial fluid; pc = parenchymal cell or myocyte.
See this image and copyright information in PMC

References

    1. Bassingthwaighte JB, Yipintsol T, Harvey RB. Microvascular of the dog left ventricular myocardium. Microvasc Res. 1974;7:229. - PMC - PubMed
    1. Duling BR, Damon DH, Desjardins C. Is microvessel perfusion heterogeneity either a controlled variable or a major cause for low capillary hematocrit? In J Microcirc Clin Exp. 1984;3:374.
    1. Ziegler WH, Goresky CA. Transcapillary exchange in the working left ventricle of the dog. Circ Res. 1971;29:181. - PubMed
    1. Barbee JH, Cokelet GR. Prediction of blood flow in tubes with diameters as small as 29 µ. Microvasc Res. 1981;3:17. - PubMed
    1. Goresky CA, Bach GG, Nadeau BE. Red cell carriage of label — its limiting effect on the exchange of materials in the liver. Circ Res. 1975;36:328. - PubMed

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