Aiming at the sweet side of cancer: aberrant glycosylation as possible target for personalized-medicine
- PMID: 24141190
- DOI: 10.1016/j.canlet.2013.10.005
Aiming at the sweet side of cancer: aberrant glycosylation as possible target for personalized-medicine
Abstract
One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer, the characteristic cell surface glycosylation is frequently transformed due to altered expression of glycan-modifying enzymes. This often leads to aberrant expression of sialic acids (Sia) that cap glycan-chains. Additionally, dietary intake of the non-human Sia N-glycolylneuraminic acid (Neu5Gc) leads to natural metabolic-glycoengineering of human carcinomas that accumulate and express Neu5Gc. This Sia provokes a polyclonal anti-Neu5Gc xeno-autoantibodies response that can exacerbate cancer. This review highlights cancer-associated changes in Sia expression and their potential for personalized-theranostics.
Keywords: Antibodies; Cancer; Neu5Gc; Personalized-medicine; Sialic acids.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
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