Comment on

• The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

  Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J. Mouchiroud L, et al. Cell. 2013 Jul 18;154(2):430-41. doi: 10.1016/j.cell.2013.06.016. Cell. 2013. PMID: 23870130 Free PMC article.
• Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.

  Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M. Schmeisser K, et al. Nat Chem Biol. 2013 Nov;9(11):693-700. doi: 10.1038/nchembio.1352. Epub 2013 Sep 29. Nat Chem Biol. 2013. PMID: 24077178 Free PMC article.