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. 1985 Nov;111(3):433-45.
doi: 10.1093/genetics/111.3.433.

Genetic analysis of mutants with a reduced Ca2+-dependent K+ current in Paramecium tetraurelia

R D Hinrichsen, E Amberger, Y Saimi, A Burgess-Cassler, C Kung

Genetic analysis of mutants with a reduced Ca2+-dependent K+ current in Paramecium tetraurelia

R D Hinrichsen et al. Genetics. 1985 Nov.

Abstract

Two mutants of Paramecium tetraurelia with greatly reduced Ca2+-dependent K+ currents have been isolated and genetically analyzed. These mutants, designated pantophobiac, give much stronger behavioral responses to all stimuli than do wild-type cells. Under voltage clamp, the Ca2+-dependent K+ current is almost completely eliminated in these mutants, whereas the Ca2+ current is normal. The two mutants, pntA and pntB, are recessive and unlinked to each other. pntA is not allelic to several other ion-channel mutants of P. tetraurelia. The microinjection of a high-speed supernatant fraction of wild-type cytoplasm into either pantophobiac mutant caused a temporary restoration to the wild-type phenotype.

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