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Meta-Analysis
. 2014 Mar;35(3):2191-7.
doi: 10.1007/s13277-013-1291-0. Epub 2013 Oct 20.

Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis

Yulan Yan  1 , Hongjie Liang, Li Xie, Yu He, Meng Li, Ruolin Li, Shan Li, Xue Qin
Affiliations
Meta-Analysis

Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis

Yulan Yan et al. Tumour Biol. 2014 Mar.

Abstract

In the light of the relationship between the MDR1 G2677T polymorphism and the risk of leukemia remains inclusive or controversial. For better understanding of the effect of MDR1 G2677T polymorphism on leukemia risk, we performed a meta-analysis. Eligible studies were identified through a search of electronic databases such as PubMed, Excerpta Medica Database (Embase), Cochrane Library, and Chinese Biomedical Literature Database (CBM). The association between the MDR1 G2677T polymorphism and leukemia risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CI). A total of seven publications including eight studies with 1,229 cases and 1,097 controls were included in the meta-analysis. There was no association between MDR1 G2677T polymorphism and leukemia risk in all of five models in overall populations (T vs. G: OR = 1.00, 95% CI = 0.88-1.12, P = 0.914; TT vs. GG: OR = 0.97, 95% CI = 0.75-1.26, P = 0.812; TG vs. GG: OR = 1.00, 95% CI = 0.92-1.08, P = 0.939; TT vs.

Tg/gg: OR = 0.98, 95% CI = 0.67-1.43, P = 0.906; TT/TG vs. GG: OR = 1.00, 95% CI = 0.95-1.06, P = 0.994). However, the significant association was found in others (Table 2) under the homozygote model (TT vs. GG: OR = 0.68, 95% CI = 0.48-0.94, P = 0.020) and recessive model (TT vs.

Tg/gg: OR = 0.63, 95% CI = 0.43-0.92, P = 0.016). In the subgroup analysis, according to the type of leukemia, significant association was found between MDR1 G2677T polymorphism and myeloid leukemia but not lymphoblastic leukemia (TT vs. GG: OR = 0.66, 95% CI = 0.46-0.95, P = 0.026; TT vs.

Tg/gg: OR = 0.56, 95% CI = 0.38-0.84, P = 0.005). The results suggested that there was no association between MDR1 G2677T polymorphism and leukemia risk in overall populations, but significant association was found in others populations (Asians and Africans), and myeloid leukemia indicated that G2677T polymorphism might be a protective factor in the susceptibility of myeloid leukemia and in Asians and Africans.

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Figures

Fig. 1
Fig. 1
a The forest plot describing the meta-analysis under recessive model for the association between MDR1 G2677T polymorphism and leukemia risk in overall population (TT vs. TG + GG). b The forest plot describing the meta-analysis subgroup analysis base on type of leukemia under recessive model for the association between MDR1 G2677T polymorphism and leukemia risk (TT vs. TG + GG). c The forest plot describing the meta-analysis subgroup analysis base on ethnicity under the homozygous model for the association between MDR1 G2677T polymorphism and leukemia risk (TT vs. GG). d Flow chart of selection of studies for inclusion in the meta-analysis
See this image and copyright information in PMC

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