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. 2013 Nov;54(6):1438-46.
doi: 10.3349/ymj.2013.54.6.1438.

Iodinated contrast media can induce long-lasting oxidative stress in hemodialysis patients

Seun Deuk Hwang  1 , Yoon Ji Kim, Sang Heun Lee, Deok Kyu Cho, Yun Hyeong Cho, Sung Jin Moon, Sang Choel Lee, Soo Young Yoon
Affiliations

Iodinated contrast media can induce long-lasting oxidative stress in hemodialysis patients

Seun Deuk Hwang et al. Yonsei Med J. 2013 Nov.

Abstract

Purpose: Due to their comorbidities, dialysis patients have many chances to undergo radiologic procedures using iodinated contrast media. We aimed to assess time-sequenced blood oxidative stress level after contrast exposure in hemodialysis (HD) patients compared to those in the non-dialysis population.

Materials and methods: We included 21 anuric HD patients [HD-coronary angiography (CAG) group] and 23 persons with normal renal function (nonHD-CAG group) scheduled for CAG, and assessed 4 oxidative stress markers [advanced oxidation protein products (AOPP); catalase; 8-hydroxydeoxyguanosine; and malondialdehyde] before and after CAG, and subsequently up to 28 days.

Results: In the nonHD-CAG group, only AOPP increased immediately after CAG and returned to baseline within one day. However, in the HD-CAG group, all four oxidative stress markers were significantly increased starting one day after CAG, and remained elevated longer than those in the nonHD-CAG group. Especially, AOPP level remained elevated for a month after contrast exposure.

Conclusion: Our study showed that iodinated contrast media induces severe and prolonged oxidative stress in HD patients.

Keywords: Oxidative stress; contrast media; hemodialysis.

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Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1
Changes in the oxidative stress markers after CAG. *p<0.05 vs. baseline. †p<0.05 vs. nonHD-CAG group. ‡p<0.05 vs. HD-control. AOPP, advanced oxidation protein products; 8-OHdG, 8-hydroxydeoxyguanosine; MDA, malondialdehyde; HD, hemodialysis; CAG, coronary angiography.
See this image and copyright information in PMC

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