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Comment
. 2013 Nov;14(11):1101-2.
doi: 10.1038/ni.2733.

No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice

Jacques Deguine  1 , Bettina L Lee, Zachary R Newman, Gregory M Barton
Affiliations
Comment

No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice

Jacques Deguine et al. Nat Immunol. 2013 Nov.
No abstract available

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Figures

Figure 1
Figure 1. Antigen presentation is unaffected in Unc93b13d/3d mice
a. Representative histograms of CFSE dilution in CD45.1+ CD4+ T cells harvested from the spleens of wild-type (WT) or Unc93b13d/3d (Unc) hosts, 3 days after injection of soluble OVA (black line, 5 mice/group) or saline as a control (solid grey, 2 mice/group). b. Percentage of divided cells (left) and the average number of divisions (right) in the CD45.1+ CD4+ T cell population harvested from the spleen or peripheral lymph nodes (pLN) of mice described in (a). c. Representative histograms of CFSE dilution in CD45.1+ CD8+ T cells harvested from the spleens of WT or Unc93b13d/3d hosts, 7 days after injection of H-2Kbm1 Act-OVA cells (black line, 6 mice/group) or H-2Kbm1 cells as a control (solid grey, 2 mice/group). d-e. Percentage of divided cells (d, left), the average number of divisions (d, right) and percentage of CD44+ cells (e) in the CD45.1+ CD8+ T cell population from the mice described in (c). f. Representative histograms (left) and the percentage (right) of IFN-γ+ cells among CD45.1+ CD8+ T cells from the peripheral lymph nodes of mice described in (c), after restimulation with OVA332-339 peptide. P-values lower than 0.05 were considered significant and denoted by a *. ** and *** denote p-values lower that 0.01 and 0.001, respectively. Error bars represent SEM.
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