Tomatoes, lysophosphatidic acid, and the small intestine: new pieces in the puzzle of apolipoprotein mimetic peptides?

Affiliations

Comment

A T Remaley. J Lipid Res. 2013 Dec.

. 2013 Dec;54(12):3223-6.

doi: 10.1194/jlr.E045054. Epub 2013 Oct 21.

¹ Lipoprotein Metabolism Section, Cardiopulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.

No abstract available

Comment on

Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid.
Navab M, Hough G, Buga GM, Su F, Wagner AC, Meriwether D, Chattopadhyay A, Gao F, Grijalva V, Danciger JS, Van Lenten BJ, Org E, Lusis AJ, Pan C, Anantharamaiah GM, Farias-Eisner R, Smyth SS, Reddy ST, Fogelman AM. Navab M, et al. J Lipid Res. 2013 Dec;54(12):3403-18. doi: 10.1194/jlr.M042051. Epub 2013 Oct 1. J Lipid Res. 2013. PMID: 24085744 Free PMC article.

1. Navab M., Reddy S. T., Van Lenten B. J., Buga G. M., Hough G., Wagner A. C., Fogelman A. M. 2012. High-density lipoprotein and 4F peptide reduce systemic inflammation by modulating intestinal oxidized lipid metabolism: novel hypotheses and review of literature. Arterioscler. Thromb. Vasc. Biol. 32: 2553–2560 - PMC - PubMed
1. Anantharamaiah G. M., Jones J. L., Brouillette C. G., Schmidt C. F., Chung B. H., Hughes T. A., Bhown A. S., Segrest J. P. 1985. Studies of synthetic peptide analogs of the amphipathic helix. Structure of complexes with dimyristoyl phosphatidylcholine. J. Biol. Chem. 260: 10248–10255 - PubMed
1. Van Lenten B. J., Navab M., Anantharamaiah G. M., Buga G. M., Reddy S. T., Fogelman A. M. 2008. Multiple indications for anti-inflammatory apolipoprotein mimetic peptides. Curr. Opin. Investig. Drugs. 9: 1157–1162 - PMC - PubMed
1. Remaley A. T., Amar M., Sviridov D. 2008. HDL-replacement therapy: mechanism of action, types of agents and potential clinical indications. Expert Rev. Cardiovasc. Ther. 6: 1203–1215 - PMC - PubMed
1. Sethi A. A., Amar M., Shamburek R. D., Remaley A. T. 2007. Apolipoprotein AI mimetic peptides: possible new agents for the treatment of atherosclerosis. Curr. Opin. Investig. Drugs. 8: 201–212 - PubMed