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. 1985 Aug;404(4):385-7.
doi: 10.1007/BF00585354.

Voltage-gated Ca2+ current in pancreatic B-cells

L S Satin, D L Cook

Voltage-gated Ca2+ current in pancreatic B-cells

L S Satin et al. Pflugers Arch. 1985 Aug.

Abstract

Voltage-dependent inward Ba++ and Ca++ currents were recorded in cultured neonatal rat pancreatic islet cells using the whole-cell voltage clamp technique. Outward current was suppressed by internal Cs+ and ATP and external TEA. Inward currents activated rapidly and decayed to a variable extent. The current decay was particularly marked when using long duration or large depolarizing pulses. Currents were due to Ca++ channel activation since they were abolished by omitting Ba++ and Ca++ or including Co++.

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