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. 2013 Jul 3;3(1):239-61.
doi: 10.3390/brainsci3010239.

Stem cell transplantation for neuroprotection in stroke

Kazutaka Shinozuka  1 , Travis Dailey, Naoki Tajiri, Hiroto Ishikawa, Yuji Kaneko, Cesar V Borlongan
Affiliations

Stem cell transplantation for neuroprotection in stroke

Kazutaka Shinozuka et al. Brain Sci. .

Abstract

Stem cell-based therapies for stroke have expanded substantially over the last decade. The diversity of embryonic and adult tissue sources provides researchers with the ability to harvest an ample supply of stem cells. However, the optimal conditions of stem cell use are still being determined. Along this line of the need for optimization studies, we discuss studies that demonstrate effective dose, timing, and route of stem cells. We recognize that stem cell derivations also provide uniquely individual difficulties and limitations in their therapeutic applications. This review will outline the current knowledge, including benefits and challenges, of the many current sources of stem cells for stroke therapy.

Keywords: cerebral ischemia; stem cells; stroke; transplantation.

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