Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Oct;3(2):67-70.
doi: 10.1055/s-0033-1338167. Epub 2013 Mar 19.

Whole blood polymerase chain reaction in a neonate with disseminated herpes simplex virus infection and liver failure

Jennifer A Scoble  1 , Mark A Underwood
Affiliations
Case Reports

Whole blood polymerase chain reaction in a neonate with disseminated herpes simplex virus infection and liver failure

Jennifer A Scoble et al. AJP Rep. 2013 Oct.

Abstract

A late preterm neonate born by cesarean section with intact membranes presented at 9 days of life with shock and liver failure. Surface cultures were negative but whole blood polymerase chain reaction was positive for herpes simplex virus type 2, underscoring the value of this test in early diagnosis of perinatally acquired disseminated herpes simplex virus infection without skin lesions.

Keywords: PCR; disseminated; herpes simplex virus; liver failure; neonate.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Magnetic resonance image obtained at day of life 10 demonstrating bilateral areas of periventricular white matter injury.
See this image and copyright information in PMC

References

    1. Hutto C, Arvin A, Jacobs R. et al. Intrauterine herpes simplex virus infections. J Pediatr. 1987;110:97–101. - PubMed
    1. Centers for Disease Control and Prevention (CDC) . Neonatal herpes simplex virus infection following Jewish ritual circumcisions that included direct orogenital suction—New York City, 2000-2011. MMWR Morb Mortal Wkly Rep. 2012;61:405–409. - PubMed
    1. Elk Grove Village, IL: American Academy of Pediatrics; 2012. Herpes Simplex.
    1. Robinson J L, Vaudry W L, Forgie S E, Lee B E. Prevention, recognition and management of neonatal HSV infections. Expert Rev Anti Infect Ther. 2012;10:675–685. - PubMed
    1. Vanderpluym C, Tawfik G, Hervas-Malo M, Lacaze-Masmonteil T, Kellner J, Robinson J L. Empiric acyclovir for neonatal herpes simplex virus infection. J Matern Fetal Neonatal Med. 2012;25:1278–1282. - PubMed

Publication types