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. 2013 Oct 18;4(4):316-22.
doi: 10.5312/wjo.v4.i4.316. eCollection 2013.

Effect of risedronate on speed of sound in postmenopausal women with osteoporosis

Jun Iwamoto  1 , Tetsuya Takada, Yoshihiro Sato, Hideo Matsumoto
Affiliations

Effect of risedronate on speed of sound in postmenopausal women with osteoporosis

Jun Iwamoto et al. World J Orthop. .

Retraction in

Abstract

Aim: To examine the effects of treatment with risedronate for 1 year on speed of sound (SOS) of the calcaneus and bone turnover markers in postmenopausal women with osteoporosis.

Methods: Thirty-eight postmenopausal women with osteoporosis who had been treated with risedronate for > 1 year were enrolled in the study. The SOS and bone turnover markers were monitored during treatment with risedronate for 1 year.

Results: The urinary levels of cross-linked N-terminal telopeptides of type I collagen and serum levels of alkaline phosphatase were significantly decreased at 3 mo (-34.7%) and 12 mo (-21.2%), respectively, compared with the baseline values. The SOS increased modestly, but significantly by 0.65% at 12 mo compared with the baseline value. Treatment with risedronate elicited an increase in the SOS of the calcaneus exceeding the coefficient of variation in vivo (0.27%).

Conclusion: The present study confirmed that risedronate suppressed bone turnover and elicited a clinically significant increase in the SOS of the calcaneus in postmenopausal women with osteoporosis.

Keywords: Bone turnover; Postmenopausal women; Quantitative ultrasound; Risedronate; Speed of sound.

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Figures

Figure 1
Figure 1
Changes in speed of sound. Data are expressed as mean ± SD. One-way analysis of variance with repeated measurements was used to analyze the longitudinal changes in the speed of sound (SOS). The longitudinal change in SOS was statistically significant (P = 0.0001 vs the baseline).
Figure 2
Figure 2
Changes in biochemical markers. Data are expressed as mean ± SD. One-way analysis of variance (ANOVA) with repeated measurements was used to analyze the longitudinal changes in biochemical markers. The longitudinal changes in serum alkaline phosphatase (ALP) and urinary cross-linked N-terminal telopeptides of type I collagen (NTX) were statistically significant (both, P < 0.0001 vs the baseline). NS: Not significant; BCE: Bone collagen equivalent.
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