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. 2014 Sep;33(3):223-7.
doi: 10.3109/15569527.2013.834498. Epub 2013 Oct 22.

Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis

Bilge Bulbul Sen  1 , Emine Nur Rifaioglu, Ozlem Ekiz, Mehmet Ugur Inan, Tugba Sen, Nihat Sen
Affiliations

Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis

Bilge Bulbul Sen et al. Cutan Ocul Toxicol. 2014 Sep.

Abstract

Objective: Psoriasis is a chronic systemic inflammatory disorder. The neutrophil to lymphocyte ratio (N/L ratio) has been used as a marker for systemic inflammatory status. In our study, we aimed to evaluate N/L ratio in patients with psoriasis.

Methods: This cross-sectional study population consisted of 138 patients with psoriasis and 120 age- and sex-matched control subjects.

Results: The patients had significantly higher neutrophil counts and lower lymphocyte counts than the controls. The N/L ratios and high sensitivity C reactive protein (hs-CRP) levels were also significantly higher in patients. The N/L ratios and hs-CRP levels were increasing with increasing in Psoriasis Area and Severity Index score. Furthermore, the N/L ratios and hs-CRP levels of patients were found to be positively correlated.

Conclusions: Our data show that the N/L ratio to be a simple, inexpensive and easily assessable marker of systemic inflammation in patients with psoriasis.

Keywords: Inflammation; neutrophil lymphocyte ratio; psoriasis.

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