Iron and transfusion medicine

Abstract

Blood bankers have focused their energy to secure blood transfusion, and only recently have studies been published on the effect of blood donation on iron metabolism. In many facilities, hemoglobin measurement is only performed just before or even during blood donation, but the determination of iron stores is largely ignored. The 2013 paradox of transfusion medicine is due to the fact that blood donation may be harmful and leads to iron deficiency with or without anemia, but for other individuals, it may be a healthy measure preventing type 2 diabetes. The purpose of this review is to discuss iron metabolism in the perspective of blood donation, notably regarding their possible genetic profiles that eventually will discriminate "good" iron absorbers from "bad" iron responders.

Keywords: GWAS; HH; Hb; IDWA; Iron; Iron deficiency anemia; Iron deficiency without anemia; Iron metabolism; Iron overload; NASH; SNP; T2D; Transfusion medicine; Type 2 diabetes; ZPP; genome wide association studies; hemoglobin; hereditary hemochromatosis; iron deficiency without anemia; nonalcoholic fatty liver disease; sTfr; single nucleotide polymorphism; soluble transferrin receptor; type 2 diabetes; zinc protoporphyrin.