doi: 10.1016/0042-6822(85)90326-5.
Identification and antigenicity of the major envelope glycoprotein of lymphadenopathy-associated virus
- PMID: 2414918
- DOI: 10.1016/0042-6822(85)90326-5
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Identification and antigenicity of the major envelope glycoprotein of lymphadenopathy-associated virus
Virology.
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Abstract
The major envelope glycoprotein of the causative agent of Acquired Immune Deficiency Syndrome (AIDS) lymphadenopathy-associated virus (LAV) has been identified and characterized. The glycoprotein has an apparent molecular weight of 110,000-120,000 under denaturing conditions in polyacrylamide gel electrophoresis. Upon deglycosylation by a specific endoglycosydase, its size is reduced to 80,000. Cellular precursors of this glycoprotein have been detected with apparent molecular weight of 150,000 and 135,000. Nearly all AIDS and pre-AIDS patients have detectable antibodies against this viral glycoprotein.
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