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. 2011 Mar 1;10(1):59-65.
eCollection 2011.

Substrate Utilization is Influenced by Acute Dietary Carbohydrate Intake in Active, Healthy Females

Sara Gregory  1 , Richard Wood, Tracey Matthews, Deborah Vanlangen, Jason Sawyer, Samuel Headley
Affiliations

Substrate Utilization is Influenced by Acute Dietary Carbohydrate Intake in Active, Healthy Females

Sara Gregory et al. J Sports Sci Med. .

Abstract

The present study compared the metabolic responses between a single low-carbohydrate (LC) and low-fat (LF) meal followed by an aerobic exercise bout in females. Subjects included 8 active, premenopausal females. Subjects completed a LC and LF testing session. Respiratory gas exchange (RER) measurements were taken for 20 min fasted, for 55 min postprandial (PP), and during 30 min of exercise. Blood was collected for assessment of glucose (G), insulin (IN), triglycerides (TG), and free fatty acids (FFA) during the final 10 min of each time period. The LF meal provided 396 kcal (78% carbohydrate, 7% fat, and 15% protein). The LC meal provided 392 kcal (15% carbohydrate, 68% fat, and 18% protein). No significant differences existed between test meals for fasting blood measurements. PP IN (μU·mL(-1)) levels were significantly lower following LC compared to LF [10.7 (6.1) vs. 26.0 (21.0)]. Postexercise (PE) FFA (mEq·L(-1)) levels were significantly greater following LC [1.1 (0.3) vs. 0.5 (0.3)]. PE TG (mg·dL(-1)) levels were significantly greater following LC [152.0 (53.1) vs. 114.4 (40.9)]. RER was significantly lower at all time points following LC compared to LF. In moderately active adult females, ingestion of a single LC meal resulted in greater lipid oxidation at rest and during exercise as compared to a single LF meal. Although macronutrient distribution appears to have dictated substrate utilization in the present study, more research is needed regarding the long-term effects of macronutrient redistribution with and without exercise on substrate utilization. Key pointsThe relative carbohydrate content of a single meal has a significant impact on postprandial metabolism and substrate utilization in healthy, active females.A single bout of aerobic exercise performed within an hour of meal ingestion has the potential to modify the postprandial response.Interventions aimed at improving body composition and preventing chronic disease should focus on dietary macronutrient redistribution and postprandial metabolism in concert with exercise training.

Keywords: Macronutrient distribution; exercise; low-carbohydrate.

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Figures

Figure 1.
Figure 1.
Mean and individual insulin responses to test meals
Figure 2.
Figure 2.
Free fatty acid levels following test meals over time.
Figure 3.
Figure 3.
Triglyceride levels following test meals over time.
See this image and copyright information in PMC

References

    1. Bowden V.L., McMurray R.G. (2000) Effects of training status on the metabolic responses to high carbohydrate and high fat meals. International Journal of Sport Nutrition and Exercise Metabolism 10, 16-27 - PubMed
    1. Burger H.G., Dudley E.C., Cui J., Dennerstein L., Hopper J.L. (2000) A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. The Journal of Clinical Endocrinology & Metabolism 85(8), 2832-2838 - PubMed
    1. Cohen J. (1988) Statistical Power Analysis for the Behavioral Sciences. 2ndedition Lawrence Eribaum Associates, Hillsdale, NJ
    1. De Glisezinski I., Moro C., Pilard F., Marion-Latard F., Harrant F., Meste M., Berian M., Crampes F., Riviere D. (2003). Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men. American Journal of Physiology, Endocrinology, & Metabolism 285, E984-E990 - PubMed
    1. Ezell D.M., Geiselman P.J., Anderson A.M., Dowdy M.L., Wombie L.G., Greenway F.L., Zachwieja J.J. (1999) Substrate oxi-dation and availability during acute exercise in non-obese, obese, and post-obese sedentary females. International Journal of Obesity, 23, 1047-1056 - PubMed

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