Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jun 1;8(2):219-24.
eCollection 2009.

Effects of Acute Moderate and Strenuous Exercise Bouts on IL-17 Production and Inflammatory Response in Trained Rats

Halil Duzova  1 , Yunus Karakoc, Memet Hanifi Emre, Zumrut Yilmaz Dogan, Evren Kilinc
Affiliations

Effects of Acute Moderate and Strenuous Exercise Bouts on IL-17 Production and Inflammatory Response in Trained Rats

Halil Duzova et al. J Sports Sci Med. .

Abstract

In this study, we aimed to compare the effects of a single bout of acute moderate and strenuous running exercise on the production of interleukin-17 (IL-17), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra) and inflammatory response of skeletal muscles in regularly trained rats. Eight week old rats were trained by treadmill running 5 days per week for 13 weeks at the durations of 30 min (moderate) and 60 min (strenuous). Two days after the last training session, the animals were subjected to a single bout of moderate or strenuous exercise and serum samples were analyzed for IL-17, IL-6, IL-1ra levels and myeloperoxidase (MPO) activity of gastrocnemius muscle were determined. IL-17 level significantly increased in strenuous exercise group when compared to that of sedentary controls (p < 0.01), On the other hand, only in the moderate exercise group, there was a negative correlation between IL-6 and IL-17 levels (r = - 0.857 and p = 0.014). In conclusion, acute single bout of strenuous exercise increased IL-17 production in trained rats and, this cytokine may be involved in inflammatory process of skeletal muscles. Key pointsA single bout of acute strenuous running exercise markedly elevated IL-17 production.This preliminary result should be supported by forthcoming studies that investigate the role of IL-17 in acute inflammatory process of skeletal muscle.

Keywords: Interleukin-17; cytokines; exercise; rat.; running.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparison of serum IL-1ra, IL-6, IL-17 levels, and muscle MPO activities (mean±standard error) among the groups. ** p < 0.01 and difference from control group.
See this image and copyright information in PMC

References

    1. Akerstrom T., Steensberg A., Keller P., Keller C., Penkowa M., Pedersen B.K. (2005) Exercise induces interleukin-8 expression in human skeletal muscle. Journal of Physiology 563(2), 507-516 - PMC - PubMed
    1. Aoi W., Naito Y., Takanami Y., Kawai Y., Sakuma K., Ichikawa H., Yoshida N., Yoshikawa T. (2004) Oxidative stress and delayed-onset muscle damage after exercise. Free Radical Biology and Medicine 37(4), 480-487 - PubMed
    1. Borish L.C., Steinke J.W. (2003) 2. Cytokines and chemokines. Journal of Allergy and Clinical Immunology 111(Suppl. 2), S460-475 - PubMed
    1. Bradley P.P., Priebat D.A., Christensen R.D., Rothstein G. (1982) Measurement of cutaneous inflamation: Estimation of neutrophil content with an enzyme marker. Journal of Investigative Dermatology 78, 206-209 - PubMed
    1. Dularay B., Elson C.J., Clements-Jewery S., Damais C., Lando D. (1990) Recombinant human interleukin-1 beta primes human polymorphonuclear leukocytes for stimulus-induced myeloperoxidase release. Journal of Leukocyte Biology 47(2), 158-163 - PubMed

LinkOut - more resources