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. 1985 Mar;123(3):261-8.
doi: 10.1111/j.1748-1716.1985.tb07586.x.

The effect of crown ethers on ionic currents in myelinated nerve fibres from Xenopus laevis

H Kristbjarnarson, P Arhem

The effect of crown ethers on ionic currents in myelinated nerve fibres from Xenopus laevis

H Kristbjarnarson et al. Acta Physiol Scand. 1985 Mar.

Abstract

The effect of several crown ethers on the currents at the node of Ranvier was studied. At differing potencies they caused a time- and potential-dependent inactivation of potassium permeability and a time- and potential-independent decrease in sodium permeability. The relative effect on potassium and sodium systems varied and was not directly related to their ionophoric properties. A computer analysis indicated that the induced inactivation was dependent on the normal potassium activation mechanism.

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