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Clinical Trial
. 1985;242(2):135-9.
doi: 10.1007/BF00454412.

A randomized clinical trial of two topical preparations (framycitin/gramicidin and oxytetracycline/hydrocortisone with polymyxin B) in the treatment of external otitis

C J Wadsten, C A Bertilsson, H Sieradzki, S Edström
Clinical Trial

A randomized clinical trial of two topical preparations (framycitin/gramicidin and oxytetracycline/hydrocortisone with polymyxin B) in the treatment of external otitis

C J Wadsten et al. Arch Otorhinolaryngol. 1985.

Abstract

In a randomized trial, 55 patients with acute external otitis were treated with either topical framycitin/gramicidin (Sofradex) or oxytetracycline/hydrocortisone (Terracortril) with polymyxin B (TPB) ear-drops for 1 week. Staphylococcus aureus and Pseudomonas pyocyanea were the bacteria most frequently found in the ear canal; 78% of the patients were cured. However, no significant differences in therapy were found when either of the preparations was used. S. aureus seemed to be most resistant to treatment, while P. pyocyanea was less of a therapeutic problem. Additionally, previous episodes of external otitis or other skin diseases did not seem to influence any treatment given.

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References

    1. Acta Otolaryngol. 1974 May;77(5):344-7 - PubMed
    1. J Med Soc N J. 1962 Sep;59:506-10 - PubMed
    1. J Laryngol Otol. 1976 May;90(5):495-7 - PubMed
    1. Acta Otolaryngol. 1981 Mar-Apr;91(3-4):285-7 - PubMed
    1. South Med J. 1962 Sep;55:910-5 - PubMed

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