doi: 10.1021/np400296s.
Epub 2013 Oct 23.
Withanolide artifacts formed in methanol
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- PMID: 24152046
- DOI: 10.1021/np400296s
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Withanolide artifacts formed in methanol
J Nat Prod.
.
Abstract
Methanol solutions of the main withanolides (6-8) naturally present in Physalis longifolia yielded five artificial withanolides (1-5), including three new compounds (1-3). Withanolides 1 and 2 were identified as intramolecular Michael addition derivatives, while withanolides 3-5 were the result of intermolecular Michael addition. A comprehensive literature investigation was conducted to identify potential withanolide Michael addition artifacts isolated from Solanaceous species to date.
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