Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Oct 24;502(7472):489-98.
doi: 10.1038/nature12752.

The nexus of chromatin regulation and intermediary metabolism

Philipp Gut  1 , Eric Verdin
Affiliations
Review

The nexus of chromatin regulation and intermediary metabolism

Philipp Gut et al. Nature. .

Abstract

Living organisms and individual cells continuously adapt to changes in their environment. Those changes are particularly sensitive to fluctuations in the availability of energy substrates. The cellular transcriptional machinery and its chromatin-associated proteins integrate environmental inputs to mediate homeostatic responses through gene regulation. Numerous connections between products of intermediary metabolism and chromatin proteins have recently been identified. Chromatin modifications that occur in response to metabolic signals are dynamic or stable and might even be inherited transgenerationally. These emerging concepts have biological relevance to tissue homeostasis, disease and ageing.

PubMed Disclaimer

References

    1. Nature. 2010 Mar 25;464(7288):504-12 - PubMed
    1. Nat Rev Drug Discov. 2012 Apr 13;11(5):384-400 - PubMed
    1. Cell. 2007 Feb 23;128(4):707-19 - PubMed
    1. Nat Rev Cancer. 2011 Sep 23;11(10):726-34 - PubMed
    1. Nature. 2012 Feb 22;483(7388):218-21 - PubMed

Publication types