Comment
doi: 10.1016/j.cub.2013.09.030.
Chromosome biology: Wapl spreads its wings
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- PMID: 24156811
- DOI: 10.1016/j.cub.2013.09.030
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Comment
Chromosome biology: Wapl spreads its wings
Curr Biol.
.
Free article
Abstract
Chromosome segregation requires the removal of cohesion and catenation between sister chromosomes, two physical linkages established during DNA replication. Two new studies reveal that, among other functions, the wings apart-like protein (Wapl) coordinates cohesin removal with decatenation of sister chromosomes during mitosis in mammalian cells.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Comment on
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Wapl is an essential regulator of chromatin structure and chromosome segregation.Nature. 2013 Sep 26;501(7468):564-8. doi: 10.1038/nature12471. Epub 2013 Aug 25. Nature. 2013. PMID: 23975099 Free PMC article.
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WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy.Curr Biol. 2013 Oct 21;23(20):2071-7. doi: 10.1016/j.cub.2013.09.003. Epub 2013 Sep 19. Curr Biol. 2013. PMID: 24055153
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