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Clinical Trial
. 2014 Mar;21(3):536-7.
doi: 10.1016/j.jocn.2013.07.001. Epub 2013 Oct 22.

Reducing post-lumbar puncture headaches with small bore atraumatic needles

Eric D Vidoni  1 , Jill K Morris  1 , Kayla Raider  2 , Jeffrey M Burns  3 ; Alzheimer’s Disease Neuroimaging Initiative
Affiliations
Clinical Trial

Reducing post-lumbar puncture headaches with small bore atraumatic needles

Eric D Vidoni et al. J Clin Neurosci. 2014 Mar.

Abstract

Lumbar puncture for testing of Alzheimer's disease pathophysiology for diagnostic confirmation is likely to become more common in the coming years. Minimizing adverse effects from this testing will be essential for clinical practice. Small bore, atraumatic needles reduce the occurrence of post-lumbar puncture headache (PLPH). Our goal was to extend this recommendation specifically to a well-characterized aging population. We assessed PLPH in the Alzheimer's Disease Neuroimaging Initiative cohort and found that PLPH occurrence was reduced only when using a 24 gauge atraumatic needle. We recommend that lumbar punctures for clinical and research purposes in Alzheimer's disease be conducted with 24 gauge atraumatic needles.

Keywords: Alzheimer’s; Biomarkers; Dementia.

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References

    1. McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):263–269. - PMC - PubMed
    1. Evans RW, Armon C, Frohman EM, Goodin DS. Assessment: prevention of post-lumbar puncture headaches: report of the therapeutics and technology assessment subcommittee of the american academy of neurology. Neurology. 2000;55(7):909–914. - PubMed
    1. Ergun U, Say B, Ozer G, et al. Intravenous theophylline decreases post-dural puncture headaches. J Clin NeurosciOct. 2008;15(10):1102–1104. - PubMed
    1. Huseyinoglu U, Huseyinoglu N, Hamurtekin E, Aygun H, Sulu B. Effect of pregabalin on post-dural-puncture headache following spinal anesthesia and lumbar puncture. J Clin Neurosci. 2011;18(10):1365–1368. - PubMed
    1. Olsen KS. Epidural blood patch in the treatment of post-lumbar puncture headache. Pain. 1987;30(3):293–301. - PubMed

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