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. 2013 Oct 25;113(10):1112-6.
doi: 10.1161/CIRCRESAHA.113.302490.

Classic studies of cultured cardiac myocyte hypertrophy: interview with a transformer

Christopher C Glembotski  1
Affiliations

Classic studies of cultured cardiac myocyte hypertrophy: interview with a transformer

Christopher C Glembotski. Circ Res. .
No abstract available

Keywords: adrenergic agents; alpha1-adrenergic receptor; cultured cardiac myocytes; heart failure; hypertrophy; muscle cells.

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Figures

Figure 1
Figure 1. Cultured Neonatal Rat Cardiac Myocyte Citation Count
Shown is the number of citations from 1975 to 2013 (August) resulting from a PubMed search using the phrase “cultured neonatal rat cardiac myocytes”.
Figure 2
Figure 2. Hypothetical Mechanism of Norepinephrine Action on Cardiac Myocyte Function
Panel A- 1985. The hypothesis from Simpson, P. Circ. Res. 1985;56:884–894 showing the actions of norepinephrine (NE), epinephrine (EPI), and isoproterenol (ISO) on α2 and β2-adrenergic receptors associated with sympathetic nerve terminals, and on α1 and β1-adrenergic receptors associated with heart cells. Panel B- 2013. Summary showing some of the major signaling processes that, as of 2013, have been found to contribute to cultured cardiac myocyte hypertrophy in response to NE. Erk1/2 = extracellular regulated kinase 1/2; PLC-β1 = phospholipase-β1; PKC = protein kinase C; CnA = calcineurin; CaMKII = calcium/calmodulin kinase II.
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