Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Oct 25;113(10):1112-6.
doi: 10.1161/CIRCRESAHA.113.302490.

Classic studies of cultured cardiac myocyte hypertrophy: interview with a transformer

Christopher C Glembotski  1
Affiliations

Classic studies of cultured cardiac myocyte hypertrophy: interview with a transformer

Christopher C Glembotski. Circ Res. .
No abstract available

Keywords: adrenergic agents; alpha1-adrenergic receptor; cultured cardiac myocytes; heart failure; hypertrophy; muscle cells.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Cultured Neonatal Rat Cardiac Myocyte Citation Count
Shown is the number of citations from 1975 to 2013 (August) resulting from a PubMed search using the phrase “cultured neonatal rat cardiac myocytes”.
Figure 2
Figure 2. Hypothetical Mechanism of Norepinephrine Action on Cardiac Myocyte Function
Panel A- 1985. The hypothesis from Simpson, P. Circ. Res. 1985;56:884–894 showing the actions of norepinephrine (NE), epinephrine (EPI), and isoproterenol (ISO) on α2 and β2-adrenergic receptors associated with sympathetic nerve terminals, and on α1 and β1-adrenergic receptors associated with heart cells. Panel B- 2013. Summary showing some of the major signaling processes that, as of 2013, have been found to contribute to cultured cardiac myocyte hypertrophy in response to NE. Erk1/2 = extracellular regulated kinase 1/2; PLC-β1 = phospholipase-β1; PKC = protein kinase C; CnA = calcineurin; CaMKII = calcium/calmodulin kinase II.
See this image and copyright information in PMC

References

    1. Simpson P, Savion S. Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol. Circ Res. 1982;50(1):101–116. - PubMed
    1. Simpson P, McGrath A, Savion S. Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines. Circ Res. 1982;51(6):787–801. - PubMed
    1. Simpson P. Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating. Circ Res. 1985;56(6):884–894. - PubMed
    1. Cohn JN, Levine TB, Olivari MT, Garberg V, Lura D, Francis GS, Simon AB, Rector T. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med. 1984;311(13):819–823. - PubMed
    1. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW. focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119(14):e391–e479. 2009. - PubMed

Publication types

Personal name as subject

LinkOut - more resources