Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Nov;62(11):3661-2.
doi: 10.2337/db13-1167.

Cholesterol accumulation in podocytes: a potential novel targetable pathway in diabetic nephropathy

Alda Tufro  1
Affiliations
Comment

Cholesterol accumulation in podocytes: a potential novel targetable pathway in diabetic nephropathy

Alda Tufro. Diabetes. 2013 Nov.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Exposure to serum from diabetic nephropathy (DN) patients or type 2 diabetic (T2D) patients induces ABCA1 downregulation, cholesterol accumulation, podocyte damage, and insulin resistance leading to albuminuria and DN progression. Methyl-β-CD (β-CD) causes cholesterol efflux, prevents podocyte damage, and rescues the insulin secretion defect. ApoA1, apolipoprotein A1.
See this image and copyright information in PMC

Comment on

  • Cyclodextrin protects podocytes in diabetic kidney disease.
    Merscher-Gomez S, Guzman J, Pedigo CE, Lehto M, Aguillon-Prada R, Mendez A, Lassenius MI, Forsblom C, Yoo T, Villarreal R, Maiguel D, Johnson K, Goldberg R, Nair V, Randolph A, Kretzler M, Nelson RG, Burke GW 3rd, Groop PH, Fornoni A; FinnDiane Study Group. Merscher-Gomez S, et al. Diabetes. 2013 Nov;62(11):3817-27. doi: 10.2337/db13-0399. Epub 2013 Jul 8. Diabetes. 2013. PMID: 23835338 Free PMC article.

References

    1. Merscher-Gomez S, Guzman J, Pedigo CE, et al. FinnDiane Study Group Cyclodextrin protects podocytes in diabetic kidney disease. Diabetes 2013;62:3817–3827 - PMC - PubMed
    1. Hudkins KL, Pichaiwong W, Wietecha T, et al. BTBR ob/ob mutant mice model progressive diabetic nephropathy. J Am Soc Nephrol 2010;21:1533–1542 - PMC - PubMed
    1. Attie AD. ABCA1: at the nexus of cholesterol, HDL and atherosclerosis. Trends Biochem Sci 2007;32:172–179 - PubMed
    1. Wang N, Silver DL, Thiele C, Tall AR. ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein. J Biol Chem 2001;276:23742–23747 - PubMed
    1. Bodzioch M, Orsó E, Klucken J, et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet 1999;22:347–351 - PubMed