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. 2013 Nov 15;15(22):5698-701.
doi: 10.1021/ol4027107. Epub 2013 Oct 25.

Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst

Rajeev Chorghade  1 , Claudio Battilocchio, Joel M Hawkins, Steven V Ley
Affiliations

Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst

Rajeev Chorghade et al. Org Lett. .

Abstract

A flow chemistry process for the Oppenauer oxidation of benzylic secondary alcohols using partially hydrated zirconium oxide and a simple carbonyl containing oxidant such as acetone, cyclohexanone, and neopentanal is reported. The heterogeneous oxidative system could be applied to a wide range of functionalized alcohol substrates, allowing clean and fast delivery of ketone products within a few minutes between 40 and 100 °C.

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