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. 1985 Dec;103(12):1870-5.
doi: 10.1001/archopht.1985.01050120104029.

Retinal pigment epithelial cells release an inhibitor of neovascularization

B M Glaser, P A Campochiaro, J L Davis Jr, M Sato

Retinal pigment epithelial cells release an inhibitor of neovascularization

B M Glaser et al. Arch Ophthalmol. 1985 Dec.

Abstract

Human retinal pigment epithelial cells in culture were found to release a substance (or substances) that causes the regression of new blood vessels on the chick embryonic yolk sac and inhibits proliferation of fetal bovine aortic endothelial cells in vitro. Neither astrocytes nor fibroblasts, under identical test conditions, released detectable inhibitors of neovascularization or endothelial cell growth. Subconfluent and superconfluent cultures of human retinal pigment epithelial cells released higher levels of inhibitor than confluent cultures.

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