RADAR: a rigorously annotated database of A-to-I RNA editing

Abstract

We present RADAR--a rigorously annotated database of A-to-I RNA editing (available at http://RNAedit.com). The identification of A-to-I RNA editing sites has been dramatically accelerated in the past few years by high-throughput RNA sequencing studies. RADAR includes a comprehensive collection of A-to-I RNA editing sites identified in humans (Homo sapiens), mice (Mus musculus) and flies (Drosophila melanogaster), together with extensive manually curated annotations for each editing site. RADAR also includes an expandable listing of tissue-specific editing levels for each editing site, which will facilitate the assignment of biological functions to specific editing sites.

Figure 1.

RADAR search page. Users can search for A-to-I editing sites in humans, mice or flies by any combination of the provided annotations: genomic location, gene, genic location, repetitive element overlap and editing conservation.

Figure 2.

Example of a RADAR search result. A search of human non-synonymous editing sites in the HTR2C gene is displayed. Hyperlinks exist in the following four columns: position, conservation, reference and editing levels. (1) Clicking on the position column will direct the user to the location of the editing site in the UCSC browser. (2) Clicking on a species name in the conservation column will direct the user to the location of the conserved editing site in the UCSC browser. (3) Clicking on the reference column will direct the user to the PubMed abstract for the study that identified the editing site. (4) Clicking on the editing level column will direct the user to tissue-specific editing level measurements for the editing site.