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. 2013:2013:295204.
doi: 10.1155/2013/295204. Epub 2013 Sep 19.

Age-related changes in trabecular meshwork imaging

Mark E Gold  1 , Seema Kansara, Kundandeep S Nagi, Nicholas P Bell, Lauren S Blieden, Alice Z Chuang, Laura A Baker, Kimberly A Mankiewicz, Robert M Feldman
Affiliations

Age-related changes in trabecular meshwork imaging

Mark E Gold et al. Biomed Res Int. 2013.

Abstract

Purpose: To evaluate the normal aging effects on trabecular meshwork (TM) parameters using Fourier domain anterior segment optical coherence tomography (ASOCT) images.

Patients and methods: One eye from 45 participants with open angles was imaged. Two independent readers measured TM area, TM length, and area and length of the TM interface shadow from 3 age groups (18-40, 41-60, and 61-80). Measurements were compared using stepwise regression analysis.

Results: The average TM parameters were 0.0487 (± 0.0092) mm(2) for TM area, 0.5502 (± 0.1033) mm for TM length, 0.1623 (± 0.341) mm(2) for TM interface shadow area, and 0.7755 (± 0.1574) mm for TM interface shadow length. Interobserver reproducibility coefficients ranged from 0.45 (TM length) to 0.82 (TM area). TM area and length were not correlated with age. While the TM interface shadow length did not correlate with age, the TM interface shadow area increased with age. Race, sex, intraocular pressure, and gonioscopy score were not correlated with any TM parameters.

Conclusion: Although the TM measurements were not correlated with age, the TM interface shadow area increased with age. Further study is required to determine whether there is any relationship between the age-related ASOCT findings of the TM interface shadow area and physiologic function.

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Figures

Figure 1
Figure 1
Anterior chamber angle anatomy. Anterior segment optical coherence tomography (ASOCT) image exhibiting Schlemm's canal (SC, green line), Schwalbe's line (SL, yellow line), and the scleral spur (SS, red dot). Trabecular meshwork (TM) length as measured is illustrated by the blue line.
Figure 2
Figure 2
Anterior chamber angle anatomy. Anterior segment optical coherence tomography (ASOCT) image with trabecular meshwork (red asterisk) and trabecular meshwork interface shadow (yellow arrow) labeled.
Figure 3
Figure 3
Anterior chamber angle parameters as identified using ACAI software. (a) Outline of the trabecular meshwork (TM) area. (b) Highlighted TM area. (c) Outline of TM interface shadow area. (d) Highlighted TM interface shadow area.
See this image and copyright information in PMC

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