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Comparative Study
. 1985 Dec 9;358(1-2):380-4.
doi: 10.1016/0006-8993(85)90989-8.

Kainic acid responses and toxicity show pronounced Ca2+ dependence

N Hori, J M Ffrench-Mullen, D O Carpenter
Comparative Study

Kainic acid responses and toxicity show pronounced Ca2+ dependence

N Hori et al. Brain Res. .

Abstract

Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that the channel activated by kainate is unusually influenced by Ca2+, excitotoxicity is Ca2+-dependent and a function of Ca2+ concentration, and the excitotoxic actions of various amino acid agonists are correlated with the Ca2+ dependence of their responses.

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